Medications

Every GLP-1 medication, compared

FDA-approved brand-names and compounded options — pricing, dosing, mechanism, and average weight loss data for each.

FDA-approved

Ozempic

Semaglutide

$998

Originally approved for type 2 diabetes, widely used off-label for weight loss. Contains semaglutide, the same active ingredient as Wegovy.

Avg weight loss: 8-14% of body weight

FDA-approved

Wegovy

Semaglutide

$1,349

FDA-approved specifically for chronic weight management. Higher dose of semaglutide than Ozempic. Oral version launched January 2026.

Avg weight loss: 15-17% of body weight

FDA-approved

Mounjaro

Tirzepatide

$1,023

First dual GLP-1/GIP receptor agonist. Approved for type 2 diabetes, used off-label for weight loss. Generally shows greater weight loss than semaglutide alone.

Avg weight loss: 15-22% of body weight

FDA-approved

Zepbound

Tirzepatide

$1,060

FDA-approved for chronic weight management. Same active ingredient as Mounjaro (tirzepatide). Shows the highest average weight loss of any currently approved GLP-1 medication.

Avg weight loss: 20-22% of body weight

FDA-approved

Rybelsus

Semaglutide (oral)

$936

First oral GLP-1 medication. Lower doses than injectable semaglutide, resulting in less weight loss. Convenient for patients who prefer pills over injections.

Avg weight loss: 5-10% of body weight

FDA-approved

Saxenda

Liraglutide

$1,350

One of the first FDA-approved GLP-1 medications for weight loss. Requires daily injections (vs weekly for newer options). Generally being replaced by more effective newer medications.

Avg weight loss: 5-8% of body weight